Pharmaceutical Analysis-1 1st Semester Unit 2 MCQs

Pharmaceutical Analysis-1 1st Semester Unit 2 MCQs

Pharmaceutical Analysis-1 1st Semester Unit 2 MCQs

Multiple Choice Questions

1.In reverse phase chromatography, the stationary phase is made up of:
a. Non-polar substance
b. Polar substance
c. Either non-polar or polar substances
d. None of these

2.A combination of paper chromatography and electrophoresis involves:
a. Partition chromatography
b. Electrical mobility of the ionic species
c. Both ‘a’ and ‘b’
d. None of these

3.Characteristic feature of any form of chromatography is the……:
a. Use of molecules that are soluble in water
b. Use of an inert carrier gas
c. Calculation of Re value for the molecules separated
d. Use of a mobile and a stationary phase

4.Thin layer chromatography can be used to distinguish between different amino acids. If a particular amino acid has low solubility in the
mobile phase used, then the amino acid……:

a. Will have a low Rf value.
b. Will spend more time dissolved in the mobile phase than attached to the stationary phase.
c. Must have a high molecular mass.
d. Will move at a speed close to that of the solvent.

5.The basis for the separation of components of a mixture in chromatographic techniques is:
a. The absorption of infrared radiation by the components.
b. The interaction of components with both stationary and mobile phases
c. The differing movements of particles of different mass in an electric field
d. The deflection of charged particle in a magnetic field

6.Pouring, dipping, spraying and spreading are the terms commonly used in:
a. Paper chromatography
b. Thin layer chromatography
c. Column chromatography

7.HPLC stands for…
a. High Pressure/ Performance Liquid Chromatography
b. High Priority Liquid Chromatography
c. Highly Placed Liquid Chromatography
d. all of the above

8.The fluid exiting from a chromatographic column is called the….:
a. Eluent
b. Eluate
c. Analyte
d. All of the above

9.The composition of Silica gel G is:
a. Silica gel without binder
b. Silica gel + CaSO4
c. Silica gel + alumina
d. Silica gel + MaSO4

10.Column chromatography separates molecules according to their…..:
a. Adsorption affinity
b. Polarity
c. Solubility
d. Matrix

11.The main principle of separation of paper chromatography is:
a. Adsorption
b. Partition coefficient
c. Ion exchange
d. Affinity

12.Choice of filter paper used in chromatography depends upon the:
a. Thickness of paper
b. Flow rate
c. Purity
d. All of the above

13.In descending development technique of paper chromatography, the….:
a. Solvent flow against gravity
b. Solvent flow down the paper
c. Solvent flow both up and down the paper
d. Solvent flows from the center and spreads in all directions

14.Paper chromatography the phenolic compounds are detected by using the reagents….:
a. Ferric compounds
b. Ninhydrin in acetone
c. Dragendroff’s reagent
d. Iodine chamber

15..Paper chromatography separates molecules according to their….:
a. Molecular size
c. Solubility
b. Polarity
d. Matrix

16..In paper and TLC separation technique the R, value is always…..
a. Less than one
b. More than one
c. Equal to one
d. All of the above

17.Activation of TLC plates means:
a. Spotting the sample over it
b. Saturation of TLC with mobile phase
c. Development of chromatogram
d. Removal of moisture from the adsorbent layer

18.Better resolution of HPLC can be obtained by:
a. Decreasing the particle size
b. Decreasing column diameter
c. Changing the flow rate
d. All of the above

19..Alumina used in chromatography are generally:
a. b-alumina
b. a-alumina
c. both a and b
d. g-alumina

20.Phenoxybenzamine acts…..
a. Directly on alpha receptor
b. By irreversibly block alpha receptor
c. By forming ethyleniminium ion
d. All of the above

21.Which of following imidazoline derivative is selective alpha-2 agonist?
a. Naphazoline
c. Clonidine
b. Tolazoline
d. None

22.Dipivefrin is prodrug of:
a. Adrenaline
b. Noradrenaline
c. Both
d. None

23.Which of long acting beta blocker is used for glaucoma?
a. Timolol
b. Carteolol
b. Levobunolol
d. Betaxolol

24.Timolol contains which of following basic rings:
a. 1,2,5-Thiadiazole and morpholine
b. 1,2,4-Thiadiazole and morpholine
c. 1,4-Thiazole and morpholine
d. None

25.The basic ring present in pilocarpine is:
a. Tetrahydrofuran and Indole
b. Tetrahydrofuran and Imidazole
c. Tetrahydrofuran and Pyrrole
d. None

26.Which of following synthetic anticholinergic derivative is used in Parkinson disease?
a. Amino alcohol ester b. Amino alcohol ether
c. Amino amide
d. None

27.Clonidine, Metronidazole and Tinidazole have basic……group in common.
a. Quinidine
b. Benzimidazole
c. Imidazoline
d. None of the above

28.Pseudoephedrine is a……of a ephedrine:
a. Erythro
b. Threo isomer
c. Meso isomer
d. Racemic mixture

29.Which isomer of propranolol is more active?
a. Meso
b. Levo
c. Dextro
d. Racemic

30.A steroid nucleus having 19 carbons is….
a. Androstane
b. Estrane
c. Gonane
d. Cholestane

31.Which of the steroids have neuromuscular blocking activity?
a. Estrogen
b. Pancuronium
c. Fusidin
d. Digitoxigenin

32.17-3-hydroxyl androst-4-ene-3-one is IUPAC name of:
a. Testosterone
b. Estradiol
c. Estriol
d. Cortisone

33.Which of following is metabolite of hydroxyzine?
a. Astemizole
b. Cetirizine
d. Terfenadine
c. Loratadine

34.The antiarrhythmic drug quinidine is a:
a. (+) Stereoisomer of quinine
b. (-) Stereoisomer of quinine
c. (+) Racemic mixture of quinine
d. None of the above

35.Which is following is NOT a prodrug?
a. Proguanil
b. Sulfasalazine
c. Prontosil red
d. Trimethoprim

36.Sulfonamides are metabolized by humans principally by:
b. Deamination
d. Conjugation
a. Acetylation
c. Oxidation

37.Which is basic ring present in sulfomethoxazole?
a. Oxazole
b. Isoxazole
c. Thiazole
d. None of the above

38.Which is the basic ring present in sulfadiazine?
a. Pyridine
b. Pyrimidine
c. Pyridazine
d. Piperidine

39.Which sulfonamide after metabolism is converted into sulfapyridine and 5-amino salicylic acid?
a. Sulfacetamide
b. Sulfamethoxazole
c. Sulfadiazine
d. Sulfasalazine

40.Which isomer of emetine is clinically useful?
a. Levo
b. Dextro
c. Cis
d. Tans-

41.Which isomer of ethambutol is clinically active?
a. Dextro
b. Levo
c. Threo
d. Erythro

42.Orally active phenazine dye is present in:
a. Pyrizinamide
b. Thiacetazone
c. Clofazimine
d. Prothionamide

43.Peptidoglycan is made up of………..amino sugar part.
a. N-acetyl glucosamine +N-acetyl muramic acid
b. N-acetyl biosamine +N-acetyl muramic acid
c. N-acetyl glucosamine + N-acetyl glucosamine
d. N-acetyl muramic acid + N-acetyl muramic acid

44.Which is NOT true in case of penicillin?
a. Good oral absorption but relatively acid labile
b. Ineffective against Gram-negative bacilli
c. Useful against Gram-positive cocci
d. Highly stable to acid /base

45.Which of the following is the ß-lactam antibiotic?
a. Penicillin & cephalosporin
b. Streptomycin & gentamycin
c. Minocyclin & doxycycline
d. Chloramphenicol

46.Which of the following is not an alkylating agent?
a. Cyclophosphamide
b. 6-Mercaptopurine
c. Chlorambucil
d. Thiotepa

47.Which of the following drugs belongs to nitrosourea group?
a. Stroptozocin
b. Carmustine
c. Lomustine
d. All of the above

48.Which of the following is a semisynthetic derivative of podophyllotoxin?
a. Etoposide
b. Mithramycin
c. Paclitaxel
d. Colchicine

49.What is the chemical name of penicillin V?
a. Phenoxy methyl penicillin
b. Benzyl penicillin
c. D-a-amino-p-hydroxy ethyl penicillin
d. 2,6-dimethoxyphenyl penicillin

50.Which of the antineoplastic agent is metabolized by xanthine oxidase?
a. 6-Mercaptopurine
b. Chlorambucil
c. Aminopterine
d. None of the above

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